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Case Number 103007 - Compositions and Methods for Targeted Drug Delivery

Description:  The present invention relates to synthetic host-rotaxanes, and in particular to novel synthetic host-rotaxanes that engage in molecular recognition events with a guest molecule to yield a host-guest complex. The present invention includes methods and compositions for transporting agents and macromolecues across biological membranes.
Although recent advances in drug delivery methods have produced active peptide and protein-based drugs, the technology suffers from a lack of suitable delivery systems. Among the problems of existing delivery systems is poor absorption of peptides through cellular membranes. The host-rotaxane of the present inventions shows almost DMSO-like ability to penetrate a cell membrane and deliver desired constituents to a cell.

Patent pending


For more information please contact Doug Nienaber at 513-558-3098 or doug.nienaber@uc.edu



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