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Case Number 106109 - G-Protein Coupled Receptor Kinase-5 Polymorphism

Description:  The present invention is directed to compositions and methods relating to a G-protein coupled receptor kinase-5 polymorphism. The methods include, for example: detecting enhanced desensitization of the beta adrenergic receptor signaling pathway in an individual, assessing partial protection against heart failure progression in an individual, and assessing an individual's response to beta-blocker therapy. The compositions include polynucleotides or fragments thereof of a nucleotide sequence encoding for a G-protein receptor kinase-5 molecule with a thymine at amino acid position 122 and oligonucleotide primers that hybridize thereto.



http://www.nature.com/nm/journal/v14/n5/abs/nm1750.html

For more information please contact Michael Hansen at 513-558-5621 or hansenmh@ucmail.uc.edu



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