Description: Our program is computer software designed to compute estimated values for transport of
chemicals through the skin. The program consists of an Excel workbook (i.e.. multiple
spreadsheets) combiried with a Visual Basic add-in that runs under Microsoft Excel on Windows XP. Some of the calculations are done in the add-in and other calculations
are done in the workbook, so that different workbooks can work with the same add-in. The
user is required to enter parameters related to the physical properties of the permeant as
well as the physical conditions he/she wants to simulate. The program returns multiple
outputs including absorption and evaporation rates. cumulative absorption and evaporation
and concentrations in the various skin layers. throughout the simulation. A key output
related to contact allergy risk assessment is C(max) the maximum concentration of permeant
achieved at the level of the mid epidermis during the absorption process. A new concept
embodied in Version 1.4 is that of calculating and separately identifying C(max) and C(free)
where C(max) is the maximum concentration of the concentration of freely diffusing permeant in the mid epidermis.
The calculations are based on a mathematical model which is subject to change as the
model becomes more sophisticated. The accuracy of the calculations will be improved and
the scope of allowable simulation conditions broadened as the development work proceeds.
For more information please contact Geoffrey Pinski at 513-558-5696 or pinskig@ucmail.uc.edu
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