Description: Dr. Giovanni Pauletti and Dr. Anil Menon have developed a novel technology to augment transport of pharmaceutical nanocarriers across biological membranes.Colloidal nanocarriers such as nanoparticles and liposomes have revolutionized drug delivery of potent pharmacological agents. Encapsulation of proteins, DNA, and siRNA into nanocarriers protects those therapeutic agents from rapid degradation and effectively limits toxic side effects. Despite being significantly smaller than conventional dosage forms, permeation of colloidal nanocarriers across biological membranes is negligible. Consequently, administration of these nanocarriers requires the use of a needle that may result in various complications, including life-threatening infections.
Invention:
This invention has the following advantages:
-
facilitates transcellular transport of intact, drug-loaded nanocarriers across epithelial cell barriers.
-
allows non-invasive, oral vaccination.
-
limits need for fetal injection during therapeutic intervention of the unborn child in utero.
A patent for this technology is pending.
More information can be found here.
For more information please contact Lynn Briggs at 513-558-3098 or briggsln@ucmail.uc.edu
