Case Number 096014 - Co-cultured Splenocyte Preparation

Contact: Ellen Monson
Email: geoffrey.pinski@uc.edu
Phone: 513-558-5274

Description:  UC researchers have developed methods of producing distinct populations of cells capable of immune suppressor and stimulatory action. Specifically, the methods relate to a combination of splenocyte and bone marrow cells, co-cultured with LPS and GM-CSF, which induce two cell subpopulations. One cell subpopulation has an immune system suppressory function capable of prolonging allograft survival when infused as a donor specific blood transfusions ("DST") with a low dose, eight day course of cyclosporine ("CSA"). Another cell subpopulation has an immune system stimulatory function capable of stimulating the immune system when infused as a DST.

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