Case Number 096014 - Co-cultured Splenocyte Preparation
Contact: Ellen Monson
Description: UC researchers have developed methods of producing distinct populations of cells capable of immune suppressor and stimulatory action. Specifically, the methods relate to a combination of splenocyte and bone marrow cells, co-cultured with LPS and GM-CSF, which induce two cell subpopulations. One cell subpopulation has an immune system suppressory function capable of prolonging allograft survival when infused as a donor specific blood transfusions ("DST") with a low dose, eight day course of cyclosporine ("CSA"). Another cell subpopulation has an immune system stimulatory function capable of stimulating the immune system when infused as a DST.
Issued - 6,165,785