Case Number 098028 - Item Number 267 - Antisense Oligonucleotides For Fertility And Menstrual Cycle Regulation And For Chemopreventive And Chemotherapeutic Use

Contact: Kellen Sensor
Email: Kellen.Sensor@uc.edu
Phone: 513-558-5621

Description:  The specific hybridization of an oligomeric compound with its target nucleic acid interferes with the normal function of the nucleic acid. This modulation of function of a target nucleic acid by compounds that specifically hybridize to it is generally referred to as “antisense.”
The present invention relates to antisense oligonucleotides, in particular to antisense oligonucleotides to receptor genes, and the use of such oligonucleotides for regulating reproductive function, for regulate estrogen synthesis, for use as a therapeutic, e.g., as chemopreventive or as a chemotherapeutic for various cancers, especially ovarian cancers, for menstrual cycle regulation, and for the management of clinical states of menstrual irregularity, menstrual dysfunction, and menopausal dysfunction. The invention also relates to pharmaceutical compositions containing antisense oligonucleotides (ODNs) that act by binding to intracellular molecular targets. Optionally, for efficient delivery to a target DNA, RNA or protein, the ODNs may be covalently linked to a carrier moiety, which facilitates delivery of the ODN to the cytosol.

Issued US Patent #7,273,932 , entitled "Antisense oligonucleotides for fertility and menstrual cycle regulation and for chemopreventive and chemotherapeutic use"