Case Number 099039 - Polymorphisms Related to Beta2 Adrenergic Receptor

Contact: Kellen Sensor
Phone: 513-558-5621

Description:  Research at the University of Cincinnati has identified genetic alterations in the beta-2 adrenergic receptor that support a method for predicting an individual's response to the .beta.-agonists salmeterol, albuterol, metaproterenol, terbutaline and formoterol. Individuals expressing the Ile164 .beta..sub.2 AR variant are likely to exhibit a reduced response as compared to individuals expressing the Thr164 .beta..sub.2 AR variant. The method is useful for making treatment decisions for patients suffering from asthma and chronic obstructive pulmonary diseases.

Issued US Patents 6,797,472 and 6,861,217