Case Number 100037 - Enhanced tPA Activity and Therapy

Contact: Jill Uhl
Email: uhlje@ucmail.uc.edu
Phone: 513-558-5621

Description:  Researchers at UC have developed methods for inhibiting lysis of coagulated blood and reducing risk of excessive lysis comprising administration of lysis-inhibiting amounts of apolipoprotein E4, and methods for inhibiting lysis of coagulated blood and reducing risk of excessive lysis comprising administration of a specific level of a lysis-inhibiting agent wherein the specific level is based on the apolipoprotein phenotype of an individual, are provided. Methods for enhancing lysis of coagulated blood by administration of an Apo E peptide fragment to blood containing a clot lysis agent are also provided.

2 Issued US patents - 7,208,288 and 7,135,305