Case Number 102064 - Novel Adsorbents and Membranes for Separation and Purification of Proteins and Related Biomolecules

Contact: Geoffrey Pinski
Phone: 513-558-5696

Description:  Mesoporous and macroporous molecular sieves are a class of chemicals which are used as adsorbents in chemical separations and purification operations involving a broad class of biologically important molecules, including but not limited to proteins, peptides, oligonucleotides, nucleic acids, enzymes and vitamins. Functionalized versions of these materials are particularly useful in carrying out separations of high efficiency and specificity.
Use of these molecular sieve materials in association with solid supports offers great promise for high-throughput industrial and commercial applications. Although several reports have demonstrated the feasibility of utilization of microporous molecular sieves (e.g., zeolite) in association with inorganic membranes, these zeolites materials are not useful for separations involving biomolecules beyond the size range of 10 Å. Previous research has not produced a method for simply and reliably producing such membranes in association with mesoporous and macroporous materials, owing to the need to assure correct orientation of the material?s pores with the underlying support.
We have developed a technique for the synthesis and characterization of novel, functionalized mesoporous and macroporous molecular sieves and their incorporation into membranes exhibiting preferential orientation of the pores with the substrate. These new materials can be functionalized in numerous ways to enhance selectivity.

  1. The technique permits the preparation of highly selective mesoporous and macroporous molecular sieves suitable for use in but not limited to either conventional chromatographic (e.g. column) applications or in association with inorganic membranes, with high mechanical durability, poison resistance, and hydrothermal stability. These systems can operate effectively in a wide range of processing conditions and demonstrate long lifetime and regenerability.
  2. Materials produced by the proprietary technique display high capacity, high absorption rates and excellent regeneration characteristics.
  3. The technique is applicable to a wide variety of porous materials covering a pore size range from 20 to 10,000 Å.